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[23] Neuropsychiatric symptoms can precede hematological signs and are often the presenting manifestation of the disease

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Figure 3 In the lymphoid compartment, PEFs induce profound responses: Enhanced CD8 + T-cell infiltration with dual Ki-67 + /PD-1 + activation ( + T-cell polarization toward IFN- + Th1/Th17 phenotypes ( Figure 3 )